Зубчатые образования толстой кишки. Актуальный обзор
https://doi.org/10.17650/2782-3202-2023-3-1-30-37
Аннотация
Зубчатые образования, как правило, считались безобидными и приравнивались патологоанатомами и гастроэнтерологами к гиперпластическим полипам. Такие представления существовали приблизительно до 2010 г. Однако недавние данные показали, что зубчатые образования потенциально могут перерасти в колоректальный рак (КРР). В классификации Всемирной организации здравоохранения выделены 4 категории зубчатых поражений: гиперпластические полипы, сидячие зубчатые поражения, традиционная зубчатая аденома и неклассифицированные зубчатые аденомы. Сидячие зубчатые поражения с дисплазией и традиционные зубчатые аденомы являются наиболее распространенными предшественниками КРР. КРР, развивающийся на фоне зубчатых образований, возникает двумя различными молекулярными путями, а именно за счет спорадической микросателлитной нестабильности и фенотипа метилирования островков CpG, причем последний рассматривается как основной механизм, который инактивирует зубчатый путь КРР. В отличие от пути аденома–карцинома, APC-инактивирующие мутации редко проявляются при зубчатых аденомах.
Ключевые слова
Об авторах
В. В. Верещак
Клинический госпиталь «Лапино» группы компаний «Мать и дитя»; ГБУЗ г. Москвы «Городская клиническая больница им. С.С. Юдина Департамента здравоохранения города Москвы»
Россия
Россия
Валерия Вадимовна Верещак
143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111
115446 Москва, Коломенский проезд, 4
И. Н. Юричев
Клинический госпиталь «Лапино» группы компаний «Мать и дитя»
Россия
Россия
143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111
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Рецензия
Для цитирования:
Верещак В.В., Юричев И.Н. Зубчатые образования толстой кишки. Актуальный обзор. MD-Onco. 2023;3(1):30-37. https://doi.org/10.17650/2782-3202-2023-3-1-30-37
For citation:
Vereshchak V.V., Iurichev I.N. Serrated colonic lesions. Current review. MD-Onco. 2023;3(1):30-37. (In Russ.) https://doi.org/10.17650/2782-3202-2023-3-1-30-37
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