Integrative approach to diagnosis of lymphoproliferative disease during long-term Sjogren’s disease. Clinical observation
P. A. Zeynalova,
G. F. Allakhverdieva,
Yu. E. Ryabukhina,
F. M. Abbasbeyli,
A. F. Batsev,
O. L. Timofeeva,
A. G. Zhukov,
T. T. Valiev https://doi.org/10.17650/2782-3202-2023-3-2-40-46
Abstract
During long-term autoimmune processes, most commonly in patients with Sjogren’s disease (SD), lymphoproliferative disorders (LPD) can develop. The risk of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) with involvement of parotid salivary glands is increased 1,000-fold compared to other immunomorphological variants. Some studies show that the main factors predisposing patients with SD to LPD are long-term enlargement of parotid salivary glands, generalized lymphadenopathy, cryoglobulinemic purpura. Application of an integrative approach to LDP diagnosis in patients with SD, identification of high-risk group for this malignant neoplasm promote its early detection.
A clinical observation of a female patients with long-term SD which was diagnosed along with MALT lymphoma using an integrative approach to diagnosis of both diseases is presented.
About the Authors
P. A. Zeynalova
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
Bld. 2, 8 Trubetskaya St., Moscow 119991
G. F. Allakhverdieva
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
Yu. E. Ryabukhina
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
Yulia Evgenyevna Ryabukhina
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
F. M. Abbasbeyli
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
A. F. Batsev
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
O. L. Timofeeva
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
A. G. Zhukov
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
T. T. Valiev
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119991
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For citations:
Zeynalova P.A., Allakhverdieva G.F., Ryabukhina Yu.E., Abbasbeyli F.M., Batsev A.F., Timofeeva O.L., Zhukov A.G., Valiev T.T. Integrative approach to diagnosis of lymphoproliferative disease during long-term Sjogren’s disease. Clinical observation. MD-Onco. 2023;3(2):41-47. (In Russ.) https://doi.org/10.17650/2782-3202-2023-3-2-40-46
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