Integrative approach to diagnosis and subsequent successful therapy of refractory follicular lymphoma using obinutuzumab in combination with bendamustine. Clinical observation
P. A. Zeynalova,
Yu. E. Ryabukhina,
F. M. Abbasbeyli,
O. L. Timofeeva,
G. F. Allakhverdieva,
D. S. Abramov,
T. T. Valiev https://doi.org/10.17650/2782-3202-2023-3-2-47-55
Abstract
In the presented observation, a female patient with diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (advanced stages) received R-ABVD regimen therapy. Return of clinical symptoms observed at the onset of the disease, as well as renewed growth of the lymph nodes after 4th therapy cycle showed refractory disease. Considering the results of earlier studies, generally showing high effectiveness of primary treatment of patients with nodular lymphocyte-predominant Hodgkin lymphoma, reevaluation of immunomorphological type of lymphoproliferative disease was performed. After change of diagnosis to grade 3A follicular lymphoma, therapy was changed to obinutuzumab in combination with bendamustine leading to fast positive antitumor effect.
About the Authors
P. A. Zeynalova
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
Bld. 2, 8 Trubetskaya St., Moscow 119991
Yu. E. Ryabukhina
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
Yulia Evgenyevna Ryabukhina
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
F. M. Abbasbeyli
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
O. L. Timofeeva
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
G. F. Allakhverdieva
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
111 1st Uspenskoe Shosse, Lapino, Moscow region 143081
D. S. Abramov
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
Russian Federation
Russian Federation
1, Zamora Mashela St., Moscow 117997
T. T. Valiev
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119991
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For citations:
Zeynalova P.A., Ryabukhina Yu.E., Abbasbeyli F.M., Timofeeva O.L., Allakhverdieva G.F., Abramov D.S., Valiev T.T. Integrative approach to diagnosis and subsequent successful therapy of refractory follicular lymphoma using obinutuzumab in combination with bendamustine. Clinical observation. MD-Onco. 2023;3(2):47-55. (In Russ.) https://doi.org/10.17650/2782-3202-2023-3-2-47-55
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