Noninvasive colorectal cancer screening techniques: literature review
https://doi.org/10.17650/2782-3202-2023-3-3-57-63
Abstract
Fecal DNA testing is a noninvasive method recommended by professional medical societies for colorectal cancer screening in individuals with intermediate risk of the disease. Adenamatous and serrated lesions, as well as cancer, lead to exfoliation of cells containing neoplastic altered DNA which, in turn, can be detected with sensitive testing methods aimed at specific genetic and epigenetic biomarkers. Mt-sDNA test approved by the United States Food and Drug Administration in 2014 showed sensitivity of 92 % for detection of colorectal cancer which is much higher than sensitivity of fecal immunochemical test (74 %).
Supporting agencies: The work was performed without external funding
About the Authors
V. V. Vereshchak
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
Valeria Vadimovna Vereshchak
143081
111 1st Uspenskoe Shosse
Moscow region
Lapino
I. N. Iurichev
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
143081
111 1st Uspenskoe Shosse
Moscow region
Lapino
A. O. Rasulov
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
143081
111 1st Uspenskoe Shosse
Moscow region
Lapino
J. M. Madyarov
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
Russian Federation
Russian Federation
143081
111 1st Uspenskoe Shosse
Moscow region
Lapino
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Review
For citations:
Vereshchak V.V., Iurichev I.N., Rasulov A.O., Madyarov J.M. Noninvasive colorectal cancer screening techniques: literature review. MD-Onco. 2023;3(3):57-63. (In Russ.) https://doi.org/10.17650/2782-3202-2023-3-3-57-63
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