Sentinel lymph node mapping in patients with uterine cancer: current state of the problem. Literature review
V. V. Polovodova,
E. V. Verenikina,
A. P. Menshenina,
O. E. Zhenilo,
A. Yu. Ardzha,
M. A. Rogozin,
N. M. Abdullayeva,
A. N. Shevchenko,
S. N. Dimitriadi https://doi.org/10.17650/2782-3202-2024-4-2-78-86
Abstract
Uterine cancer is one of the most common malignant diseases among female population. Surgical treatment is the main part of therapy but the question of lymph node dissection volume in patients with intermediate risk of uterine cancer metastasis remains open.
The article considers the concept of sentinel lymph node, anatomical characteristics of uterine lymphatic system. Description of various techniques for identification of sentinel lymph nodes, as well as clinical trial data evaluating their diagnostic effectiveness and sensitivity, are presented. Comparative analysis of the techniques and their combinations, drug administration routes is performed.
About the Authors
V. V. Polovodova
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Veronika V. Polovodova
63 14th Line St., Rostov-on-Don 344037
E. V. Verenikina
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
A. P. Menshenina
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
O. E. Zhenilo
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
A. Yu. Ardzha
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
M. A. Rogozin
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
N. M. Abdullayeva
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
A. N. Shevchenko
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
S. N. Dimitriadi
National Medical Research Center for Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
63 14th Line St., Rostov-on-Don 344037
References
1. Kit O.I., Kovalenko N.V., Maksimov A.Yu., Verenikina E.V. Bioinformational and clinical aspects of identification of differentially expressed genes by tumor cells in endometrial carcinoma and rare forms of uterine body cancer. Meditsinskiy vestnik Severnogo Kavkaza = Medical News of the North Caucasus 2023;18(1):37–41. (In Russ.). DOI: 10.14300/mnnc.2023.18009
2. Rykov M.Yu., Venediktova M.G. Clinical lectures on oncogynecology: a guide. Moscow: GEOTAR-Media, 2022. 320 p. (In Russ.). DOI: 10.33029/9704-6967-5-КTO-2022-1-320
3. Oncogynecology: national guide. Ed. by A.D. Kaprin, L.A. Ashrafyan, I.S. Stylidi. Moscow: GEOTAR-Media, 2023. 384 p. (In Russ.). DOI: 10.33029/9704-5329-2-ONR-2019-1-384
4. Wagner M.M., van der Zee A.G.J., Oonk M.H.M. History and updates of the GROINSS-V studies. Cancers (Basel) 2022;14(8):1956. DOI: 10.3390/cancers14081956
5. Kagan I.I. Clinical anatomy of the female pelvis: illustrated author’s cycle of lectures. Ed. by G.T. Sukhikh. Moscow: GEOTAR-Media, 2021. 152 p. (In Russ.).
6. Nechushkina V.M., Kolomiets L.A., Kravets O.A. et al. Practical recommendations for the drug treatment of the uterine body cancer and uterine sarcomas. Practical recommendations of the Russian Society of Clinical Oncology. Part 1. Zlokachestvenniye opukholi = Malignant Tumors 2023;13(3S2):263–79. (In Russ.). DOI: 10.18027/2224-5057-2023-13-3s2-1-263-279
7. Tanis P.J., Nieweg O.E., Vald’s Olmos R.A. et al. History of sentinel node and validation of the technique. Breast Cancer Res 2001;3(2):109–12. DOI: 10.1186/bcr281
8. Gould E.A., Winship T., Philbin P.H., Kerr H.H. Observations on a “sentinel node” in cancer of the parotid. Cancer 1960;13:77–8. DOI: 10.1002/1097-0142(196001/02)13:13.0.co;2-d
9. Cabanas R.M. An approach for the treatment of penile carcinoma. Cancer 1977;39(2):456–66. DOI: 10.1002/1097-0142(197702)39:23.0.co;2-i
10. Salman L., Cusimano M.C., Marchocki Z., Ferguson S.E. Sentinel lymph node mapping in high-grade endometrial cancer. Curr Oncol 2022;29(2):1123–35. DOI: 10.3390/curroncol29020096
11. Krag D.N., Anderson S.J., Julian T.B. et al. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol 2010;11(10):927–33. DOI: 10.1016/S1470-2045(10)70207-2
12. Oonk M.H., van Hemel B.M., Hollema H. et al. Size of sentinelnode metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol 2010;11(7):646–52. DOI: 10.1016/S1470-2045(10)70104-2
13. Morton D.L., Wen D.R., Wong J.H. et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992;127(4):392–9. DOI: 10.1001/archsurg.1992.01420040034005
14. Giuliano A.E., Kirgan D.M., Guenther J.M., Morton D.L. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 1994;220(3):391–8; discussion 398–401. DOI: 10.1097/00000658-199409000-00015
15. Restaino S., Ronsini C., Finelli A. et al. Role of blue dye for sentinel lymph node detection in early endometrial cancer. Gynecol Surg 2017;14(1):23. DOI: 10.1186/s10397-017-1026-0
16. Du J., Li Y., Wang Q. et al. Sentinel lymph node mapping in gynecological oncology. Oncol Lett 2017;14(6):7669–75. DOI: 10.3892/ol.2017.7219
17. Bézu C., Coutant C., Salengro A. et al. Anaphylactic response to blue dye during sentinel lymph node biopsy. Surg Oncol 2011;20(1):e55–9. DOI: 10.1016/j.suronc.2010.10.002
18. Krag D.N., Weaver D.L., Alex J.C., Fairbank J.T. Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol 1993;2(6):335–9; discussion 340. DOI: 10.1016/0960-7404(93)90064-6
19. Perissinotti A., Paredes P., Vidal-Sicart S. et al. Use of SPECT/CT for improved sentinel lymph node localization in endometrial cancer. Gynecol Oncol 2013;129(1):42–8. DOI: 10.1016/j.ygyno.2013.01.022
20. Chernov V.I., Sinilkin I.G., Zelchan R.V. et al. Experimental study of 99mTc-aluminum oxide use for sentinel lymph nodes detection. Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC’16). AIP Conf Proc 2016;1760:020012. DOI: 10.1063/1.4960231
21. Chemyshova A.L., Kolomiets L.A., Sinilkin I.G. et al. Optimization of the extent of surgical treatment in patients with stage I in cervical cancer. Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC’16). AIP Conf Proc 2016;1760:020013. DOI: 10.1063/1.4960232
22. Eshima D., Fauconnier T., Eshima L., Thornback J.R. Radiopharmaceuticals for lymphoscintigraphy: including dosimetry and radiation considerations. Semin Nucl Med 2000;30(1):25–32. DOI: 10.1016/S0001-2998(00)80059-8
23. Unkart J.T., Hosseini A., Wallace A.M. Tc-99m tilmanocept versus Tc-99m sulfur colloid in breast cancer sentinel lymph node identification: results from a randomized, blinded clinical trial. J Surg Oncol 2017;116(7):819–23. DOI: 10.1002/jso.24735
24. Chernyshova L.A., Kolomiets L.A., Chernov V.I. Radical trachelectomy for cervical cancer. Novosibirsk: Siberian Branch of RAS, 2020. 147 p. (In Russ.).
25. Chernyshova A.L., Kolomiec L.A., Chernov V.I., Sinilkin I.G. Detection of sentinel lymph nodes in organ-preserving treatment for invasive cervical cancer. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2018;17(1):82–91. (In Russ.). DOI: 10.21294/1814-48612018-17-1-82-91
26. Pollard J.H., Raman C., Zakharia Y. et al. Quantitative test-retest measurement of 68Ga-PSMA-HBED-CC in tumor and normal tissue. J Nucl Med 2020;61(8):1145–52. DOI: 10.2967/jnumed.119.236083
27. Shevchuk A.S., Krylov A.S., Knyazev R.I., Afanasieva K.V. Determination of sentinel lymph nodes in gynecological cancer using the radiopharmaceutical sentiscan. A case series. Sovremennaya onkologiya = Journal of Modern Oncology 2023;25(1): 91–8. (In Russ.). DOI: 10.26442/18151434.2023.1.202140
28. Kraft O., Havel M. Detection of sentinel lymph nodes in gynecologic tumours by planar scintigraphy and SPECT/CT. Mol Imaging Radionucl Ther 2012;21(2):47–55. DOI: 10.4274/Mirt.236
29. Kanaev S.V., Bisyarin M.I., Krzhivitskiy P.I. et al. Preoperative SPECT-CT visualization of sentinel lymph nodes in patients with cervical cancer: preliminary analysis of the data. Voprosy onkologii = Problems in Oncology 2019;65(4):524–31. (In Russ.). DOI: 10.37469/0507-3758-2019-65-4-524-531
30. Bosenko E.S., Luganskaya R.G., Shatova Yu.S. et al. Experience of sentinel lymph node biopsy technique in patients with breast cancer at Rostov Research Institute of Oncology. Mezhdunarodniy zhurnal prikladnikh i fundamentalnikh issledovaniy = International Journal of Applied and Fundamental Research 2019;5:57–61. (In Russ.).
31. Handgraaf H.J., Verbeek F.P., Tummers Q.R. et al. Real-time nearinfrared fluorescence guided surgery in gynecologic oncology: a review of the current state of the art. Gynecol Oncol 2014;135:606–13. DOI: 10.1016/j.ygyno.2014.08.005
32. Bogani G., Raspagliesi F., Leone Roberti Maggiore U., Mariani A. Current landscape and future perspective of sentinel node mapping in endometrial cancer. J Gynecol Oncol 2018;29(6):e94. DOI: 10.3802/jgo.2018.29.e94
33. Frumovitz M., Plante M., Lee P.S. et al. Near-infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial. Lancet Oncol 2018;19(10):1394–403. DOI: 10.1016/S1470-2045(18)30448-0
34. Sinno A.K., Fader A.N., Roche K.L. et al. A comparison of colorimetric versus fluorometric sentinel lymph node mapping during robotic surgery for endometrial cancer. Gynecol Oncol 2014;134(2):281–6. DOI: 10.1016/j.ygyno.2014.05.022
35. Persson J., Salehi S., Bollino M. et al. Pelvic sentinel lymph node detection in High-Risk Endometrial Cancer (SHREC-trial)- the final step towards a paradigm shift in surgical staging. Eur J Cancer 2019;116:77–85. DOI: 10.1016/j.ejca.2019.04.025
36. Alimov V.A., Skugarev S.A., Grekov D.N. et al. Diagnostic value of ICG for sentinel lymph node mapping in patients with stage I endometrial cancer. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2023;22(6):35–44. (In Russ.). DOI: 10.21294/1814-4861-2023-22-6-35-44
37. Van de Lande J., Torrenga B., Raijmakers P.G. et al. Sentinel lymph node detection in early stage uterine cervix carcinoma: a systematic review. Gynecol Oncol 2007;106(3):604–13. DOI: 10.1016/j.ygyno.2007.05.010
38. Niikura H., Kaiho-Sakuma M., Tokunaga H. et al. Tracer injection sites and combinations for sentinel lymph node detection in patients with endometrial cancer. Gynecol Oncol 2013;131(2):299–303. DOI: 10.1016/j.ygyno.2013.08.018
39. Berlev I.V., Ulrikh E.A., Ibragimov Z.N. et al. Possibilities of detection of sentinel lymph nodes in endometrial cancer by radioisotope and fluorescent (ICG) methods. Voprosy onkologii = Problems in Oncology 2017;63(2):304–8. (In Russ.). DOI: 10.37469/0507-3758-2017-63-2-304-308.
40. Buda A., Crivellaro C., Elisei F. et al. Impact of indocyanine green for sentinel lymph node mapping in early stage endometrial and cervical cancer: comparison with conventional radiotracer 99mTc and/or blue dye. Ann Surg Oncol 2016;23(7):2183–91. DOI: 10.1245/s10434-015-5022-1
41. Verbeek F.P., Tummers Q.R., Rietbergen D.D. et al. Sentinel lymph node biopsy in vulvar cancer using combined radioactive and fluorescence guidance. Int J Gynecol Cancer 2015;25(6):1086–93. DOI: 10.1097/IGC.0000000000000419
42. Eriksson A.G., Montovano M., Beavis A. et al. Impact of obesity on sentinel lymph node mapping in patients with newly diagnosed uterine cancer undergoing robotic surgery. Ann Surg Oncol 2016;23(8):2522–8. DOI: 10.1245/s10434-016-5134-2
43. Abu-Rustum N.R. Sentinel lymph node mapping for endometrial cancer: a modern approach to surgical staging. J Natl Compr Cancer Network 2014;12(2):288–97. DOI: 10.6004/jnccn.2014.0026
44. Reneé Franklin C., Tanner E.J. 3rd. Where are we going with sentinel lymph node mapping in gynecologic cancers? Curr Oncol Rep 2018;20(12):96. DOI: 10.1007/s11912-018-0744-4
45. Abu-Rustum N.R., Khoury-Collado F., Gemignani M.L. Techniques of sentinel lymph node identification for early-stage cervical and uterine cancer. Gynecol Oncol 2008;111(2 Suppl): S44–50. DOI: 10.1016/j.ygyno.2008.07.027
46. Khoury-Collado F., Abu-Rustum N.R. Lymphatic mapping in endometrial cancer: a literature review of current techniques and results. Int J Gynecol Cancer 2008;18(6):1163–8. DOI: 10.1111/j.1525-1438.2007.01188.x
47. Cousins A., Thompson S.K., Wedding A.B., Thierry B. Clinical relevance of novel imaging technologies for sentinel lymph node identification and staging. Biotechnol Adv 2014;32(2):269–79. DOI: 10.1016/j.biotechadv.2013.10.011
48. Ditto A., Casarin I., Pinelli C. et al. Hysteroscopic versus cervical injection for sentinel node detection in endometrial cancer: a multicenter prospective randomised controlled trial from the Multicenter Italian Trials in Ovarian cancer (MITO) study group. Eur J Cancer 2020;140:1–10. DOI: 10.1016/j.ejca.2020.08.030
49. Cormier B., Rozenholc A.T., Gotlieb W. et al. Sentinel lymph node procedure in endometrial cancer: a systematic review and proposal for standardization of future research. Gynecol Oncol 2015;138(2):478–85. DOI: 10.1016/j.ygyno.2015.05.039
50. Abu-Rustum N., Yashar C., Arend R. et al. Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2023;21(2):181–209. DOI: 10.6004/jnccn.2023.0006
51. Concin N., Matias-Guiu X., Vergote I. et al. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer 2021;31(1):12–39. DOI: 10.1136/ijgc-2020-002230
Review
For citations:
Polovodova V.V., Verenikina E.V., Menshenina A.P., Zhenilo O.E., Ardzha A.Yu., Rogozin M.A., Abdullayeva N.M., Shevchenko A.N., Dimitriadi S.N. Sentinel lymph node mapping in patients with uterine cancer: current state of the problem. Literature review. MD-Onco. 2024;4(2):78-86. (In Russ.) https://doi.org/10.17650/2782-3202-2024-4-2-78-86
Views:
188
Email this article 