Prospects for the use of transcranial magnetic stimulation in the rehabilitation of children with brain tumors. Literature review
V. Kh. Kharbediya,
M. A. Kapranova,
E. A. Salenko,
A. A. Glazyrina,
E. E. Petryaykina,
E. V. Kumirova https://doi.org/10.17650/2782-3202-2025-5-1-77-83
Abstract
Transcranial magnetic stimulation (TMS) is a neuromodulation technology capable of targeted stimulation and inhibition of cortical areas of the brain. Currently, TMS has established itself as a method with proven effectiveness in the treatment of some psychoneurological disorders in children. In this regard, there is increasing interest in studying new options for the use of TMS in patients with acute and chronic neurological deficits. In children with brain tumors, up to 90 % of neurological disorders are determined. However, to date, there is insufficient data on the use of TMS technology in pediatric oncological neurorehabilitation.
About the Authors
V. Kh. Kharbediya
Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Vakhtang Khvichevich Kharbediya
4a Vysotnaya St., Podolsk, Moscow region 142114
M. A. Kapranova
Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
4a Vysotnaya St., Podolsk, Moscow region 142114
E. A. Salenko
Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
4a Vysotnaya St., Podolsk, Moscow region 142114
A. A. Glazyrina
Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
4a Vysotnaya St., Podolsk, Moscow region 142114
E. E. Petryaykina
Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
117 Leninskiy Ave., Moscow 119571
E. V. Kumirova
Morozovskaya City Children’s Clinical Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
1/9 4th Dobryninsky Ln., Moscow 119049
References
1. Valiev T.T., Morozova O.V., Kovrigina A.M. et al. Diagnosis and treatment of anaplastic large cell lymphomas in children. Hematologiya i transfuzilogiya = Hematology and Transfusiology 2012;57(1):3–9. (In Russ.).
2. Valiev T.T., Popa A.V., Levashov A.S. et al. NonHodgkin’s lymphoma in children: 25 years of therapy. Klinicheskaya onkogematologiya = Clinical Oncohematology 2016;9(4):420–37. (In Russ.). DOI: 10.21320/25002139201694420437
3. Levashov A.S., Zagidullina S.R., Valiev T.T. et al. Experience of LIKESJMB03 protocol in treatment of children with medulloblastoma in the age group over 3 years: results of an intercenter pilot study. Sovremennaya onkologiya = Journal of Modern Oncology 2024;26(1):80–6. (In Russ.). DOI: 10.26442/18151434.2024.1.202594
4. Valiev T.T., Shervashidze M.A., Belysheva T.S. Toxicity assessment of acute lymphoblastic leukemia treatment protocol ALL ICBFM 2002. Onkogematologiya = Oncohematology 2022;17(3):137–59. (In Russ.). DOI: 10.17650/181883462022173137159
5. Gurieva O.D., Savelyeva M.I., Valiev T.T. Genetic basis of clinical variants of chemotherapy toxicity in children with acute lymphoblastic leukemia (literature review). Rossiyskiy zhurnal detskoy gemaologii i onkologii = Russian Journal of Pediatric Hematology and Oncology 2021;8(4):6070. (In Russ.) DOI: 10.21682/231112672021846070
6. Piradov M.A., Bakulin I.S., Zabirova A.Kh. et al. Transcranial magnetic stimulation in clinical and research practice. Ed. by M.A. Piradov. Moscow: Nauchnoye izdaniye, 2024. 584 p.
7. Klomjai W., Katz R., LackmyVallee A. Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS). Ann Phys Rehabil Med 2015;58(4):208–13. DOI: 10.1016/j.rehab.2015.05.005
8. Lagoda D.Yu., Dobrynina L.A., Suponeva N.A. et al. Repetitive transcranial magnetic stimulation in the treatment of mild cognitive impairment due to cerebral small vessel disease. Annaly klinicheskoy i eksperimentalnoy nevrologii = Annals of Clinical and Experimental Neurology 2021;15(4):5–14. DOI: https://doi.org/10.54101/ACEN.2021.4.1
9. Maeda F., Keenan J.P., Tormos J.M. et al. Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation. Clin Neurophysiol 2000;111(5):800–5. DOI: 10.1016/s13882457(99)003235
10. Berardelli A., Inghilleri M., Rothwell J.C. et al. Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp Brain Res 1998;122(1):79–84. DOI: 10.1007/s002210050493
11. George M.S., Lisanby S.H., Avery D. et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a shamcontrolled randomized trial. Arch Gen Psychiatry 2010;67(5):507–16. DOI: 10.1001/archgenpsychiatry.2010.46
12. George M.S., Wassermann E.M., Kimbrell T.A. et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebocontrolled crossover trial. Am J Psychiatry 1997;154(12):1752–6. DOI: 10.1176/ajp.154.12.1752
13. O’Reardon J.P., Solvason H.B., Janicak P.G. et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007;62(11):1208–16. DOI: 10.1016/j.biopsych.2007.01.018
14. Yan J. FDA approves new option to treat major depression. Psychiatric News 2008;43(22):2–17. DOI: 10.1176/pn.43.22.0002
15. Chung S.W., Hill A.T., Rogasch N.C. et al. Use of thetaburst stimulation in changing excitability of motor cortex: a systematic review and metaanalysis. Neurosci Biobehav Rev 2016;63:43–64. DOI: 10.1016/j.neubiorev.2016.01.008
16. Hoyer E.H., Celnik P.A.. Understanding and enhancing motor recovery after stroke using transcranial magnetic stimulation. Restor Neurol Neurosci 2011;29(6):395–409. DOI: 10.3233/RNN20110611
17. Hummel F.C., Cohen L.G. Noninvasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? Lancet Neurol 2006;5(8):708–12. DOI: 10.1016/S14744422(06)705257
18. He Y., Zhang Q., Ma T.T. et al. Effect of repetitive transcranial magnetic stimulationassisted training on lower limb motor function in children with hemiplegic cerebral palsy. BMC Pediatr 2024;24(1):136. DOI: 10.1186/s12887024046055
19. Xie Y.J., Chen Y., Tan H.X. et al. Repetitive transcranial magnetic stimulation for lower extremity motor function in patients with stroke: a systematic review and network metaanalysis. Neural Regeneration Research 2021;16(6):1168–76. DOI: 10.4103/16735374.300341
20. Tarapore P.E., Picht T., Bulubas L. et al. Safety and tolerability of navigated TMS for preoperative mapping in neurosurgical patients. Clin Neurophysiol 2016;127(3):1895–900. DOI: 10.1016/j.clinph.2015.11.042
21. Kakuda W., Abo M., Kobayashi K. et al. Lowfrequency rTMS combined with intensive occupational therapy for upper limb hemiparesis after brain tumour resection. Brain Injury 2010;24(12):1505–10. DOI: 10.3109/02699052.2010.523040
22. Barcia J.A., Sanz A., GonzálezHidalgo M. et al. rTMS stimulation to induce plastic changes at the language motor area in a patient with a left recidivant brain tumor affecting Brocaʼs area. Neurocase 2012;18(2):132–8. DOI: 10.1080/13554794.2011.568500
23. OʼNeal C.M., Stephens T.M., Briggs R.G. et al. Navigated transcranial magnetic stimulation following awake craniotomy for resection of glioma: description of two cases. Surg Neurol Int 2020;11:433. DOI: 10.25259/SNI_628_2020
24. Ille S., Kelm A., Schroeder A. et al. Navigated repetitive transcranial magnetic stimulation improves the outcome of postsurgical paresis in glioma patients – a randomized, doubleblinded trial. Brain Stimul 2021;14(4):780–7. DOI: 10.1016/j.brs.2021.04.026
25. Poologaindran A., Profyris C., Young I.M. et al. Interventional neurorehabilitation for promoting functional recovery postcraniotomy: a proofofconcept. Sci Rep 2022;12(1):3039. DOI: 10.1038/s41598022067668
26. Rossi S., Antal A., Bestmann S. et al. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines. Clin Neurophysiol 2021;132(1):269–306. DOI: 10.1016/j.clinph.2020.10.003
27. Hausmann A., Kemmler G., Walpoth M. et al. No benefit derived from repetitive transcranial magnetic stimulation in depression: a prospective, single centre, randomised, double blind, sham controlled “add on” trial. J Neurol Neurosurg Psychiatry 2004;75(2):320–2.
28. Siddiqi S.H., Taylor S.F., Cooke D. et al. Distinct symptomspecific treatment targets for circuitbased neuromodulation. Am J Psychiatry 2020;177(5):435–46. DOI: 10.1176/appi.ajp.2019.19090915
29. Rosen A.C., Bhat J.V., Cardenas V.A. et al. Targeting location relates to treatment response in active but not sham rTMS stimulation. Brain Stimul 2021;14(3):703–9. DOI: 10.1016/j.brs.2021.04.010
30. Dadario N.B., Brahimaj B., Yeung J., Sughrue M.E. Reducing the cognitive footprint of brain tumor surgery. Front Neurol 2021;12:711646. DOI: 10.3389/fneur.2021.711646
31. MorenoOrtega M., Kangarlu A., Lee S. et al. Parcelguided rTMS for depression. Translational Psychiatry 2020;10(1):283 DOI: 10.1038/s41398020009708
32. Einstein E.H., Dadario N.B., Khilji H. et al. Transcranial magnetic stimulation for postoperative neurorehabilitation in neurooncology: a review of the literature and future directions. J Neurooncol 2022;157(3):435–43. DOI: 10.1007/s11060022039879
Review
For citations:
Kharbediya V.Kh., Kapranova M.A., Salenko E.A., Glazyrina A.A., Petryaykina E.E., Kumirova E.V. Prospects for the use of transcranial magnetic stimulation in the rehabilitation of children with brain tumors. Literature review. MD-Onco. 2025;5(1):77-83. (In Russ.) https://doi.org/10.17650/2782-3202-2025-5-1-77-83
Views:
79
Email this article 