In the era of minimally invasive surgery for colorectal cancer, more and more studies are devoted to improving surgical techniques of intracorporeal ileo-colic anastomosis. In this article, we demonstrate our own experience in performing a hardware, intracorporeal, antiperistaltic ileo-transverse anastomosis in three patients after laparoscopic right hemicolectomy for right colon cancer. This type of anastomosis can become a good alternative to an intracorporeal isoperistaltic anastomosis, reducing the time and cost of the surgical procedure.

The use of highly effective combinations of pharmaceutical agents in the 1^st line therapy of multiple myeloma promotes higher survival in all patient subgroups including high-risk patients. The presence of bone plasmacytoma with soft tissue components and spinal cord compression, pathological compression fractures of vertebral bodies worsen prognosis by increasing the probability of neurologic deficit development and quick progression at any stage. Therefore, the use of multidisciplinary approach is justified.
A clinical observation of a 65-year-old patient with multiple myeloma manifesting through bone plasmacytomas with massive soft-tissue components and complicated by pathological compression fracture of the Th₂ vertebra with neurologic deficit is presented. After the appearance of clinical symptoms of compression, surgical intervention was urgently performed (decompression laminectomy, subtotal resection of the tumor at the Th₂–Th₃ vertebra level) with partial mobilization of the patient in the early postoperative period. Antitumor drug therapy was started (daratumumab, lenalidomide, dexamethasone – D-Rd regimen) demonstrating positive effect.

Aim. To study the clinical, morphological and molecular genetic characteristics of serrated formations of colorectal localization.

Materials and methods. The study included 73 patients aged from 28 to 84 years with 92 serrated colon formations, who underwent colonoscopy with biopsy. The average age of men is 64.5 years, for women – 54.7 years. Next, a morphological, immunohistochemical and molecular genetic study was carried out.

Results. According to histological examination, sessile serrated adenomas (SSA) of the colon were most often found (47.5 %), hyperplastic polyp (HP) and traditional serrated adenoma (TSA) were found less frequently and with the same frequency (25.4 % each). The most typical location for SSA was the right half of the colon, for TSA – the left. HP was determined evenly in both halves of the colon. An immunohistochemical study of the subtypes revealed no significant differences in the expression of markers. In 50 % of SSA, a mutation in the BRAF gene was detected, 41.7 % of HP had a genetic mutation of BRAF, 16.6 % had a mutation of KRAS. In 58.4 % of TSA, a KRAS mutation was detected, in 8.3 % – BRAF, and in 33.3 % there was no gene mutation.

Conclusion. As a result of our study, it was found that the types of serrated adenomas have significant differences depending on the gender and age of the patients, as well as on the DNA structure. In addition, they differ in molecular genetic characteristics.

The level of serum ferritin is elevated in many malignant tumors. Ferritin concentration in serum should be considered a clinically useful tumor marker representing a significant and simple parameter for disease activity monitoring.
Aim of the work is to present a clinical case of a 74-year-old female patient with a diagnosis of “bone and lung metastases without primary tumor, stage IV, 2nd clinical group” (per the International Classification of Diseases 10th revision: С79.5. Secondary malignant neoplasm of bone and bone marrow), determine diagnostic and prognostic value of ferritin levels in some types of cancer.
Due to worsening condition in the form of increased fatigue, bone pain, food refusal, the patient sought a consultation with an oncologist and was referred for hospitalization in a therapy unit with the main diagnosis of “D50.9. Iron deficiency anemia, unspecified” and concomitant diagnosis of “Kaposi’s sarcoma of the skin?” Biochemical blood work showed high ferritin levels. The presented clinical case demonstrated high diagnostic and prognostic value of ferritin level as not only iron depot but also as an acute phase protein. It is known that aberrant ferritin expression is associated with various malignant neoplasms, and high ferritin levels accompany severe diseases. In the case of our patient, the increase in this parameter showed progression of oncological process.

Brain tumors are the most common solid tumors in children and are associated with high mortality. The most common childhood brain tumors are grouped as low­grade gliomas, high grade gliomas, ependymomas, and embryonal tumors, according to the World Health Organization (WHO). Advances in molecular genetics have led to a shift from pure histopathological diagnosis to integrated diagnosis. For the first time, these new criteria were included in the WHO classification published in 2016 and has been further updated in the 2021 edition. Integrated diagnosis is based on molecular genomic similarities of the tumor subclasses, and it can better explain the differences in clinical courses of previously histopathologically identical entities. Important advances have also been made in pediatric neuro­oncology. A growing understanding of the molecular­genetic background of tumorigenesis has improved the diagnostic accuracy. Re­stratification of treatment protocols and the development of targeted therapies will significantly affect overall survival and quality of life. For some pediatric tumors, these advances have significantly improved therapeutic management and prognosis in certain tumor subgroups. Some therapeutic approaches also have serious long­term consequences. Therefore, optimized treatments are greatly needed.

Immune thrombocytopenia in patients with concomitant cardiovascular disorders requiring antiplatelet and anticoagulant therapy can increase the risk of hemorrhages and arterial and venous thromboembolic complications. This situation necessitates special patient management. Multidisciplinary approach is important for patients requiring myocardial revascularization due to the necessity of administration of double or triple antiplatelet therapy.
The article presents our experience in management of patients with immune thrombocytopenia and high functional class stable angina requiring coronary artery stent.

Nutrition support is a key component of accompanying therapy in children who have undergone hematopoietic stem cell transplantation. Complications and side effects may occur at all stages of treatment, which require monitoring and correction of nutritional status. The article presents an analysis of current recommendations and a review of studies on clinical nutrition in children after hematopoietic stem cell transplantation.

Transcranial magnetic stimulation (TMS) is a neuromodulation technology capable of targeted stimulation and inhibition of cortical areas of the brain. Currently, TMS has established itself as a method with proven effectiveness in the treatment of some psychoneurological disorders in children. In this regard, there is increasing interest in studying new options for the use of TMS in patients with acute and chronic neurological deficits. In children with brain tumors, up to 90 % of neurological disorders are determined. However, to date, there is insufficient data on the use of TMS technology in pediatric oncological neurorehabilitation.